Publications of Eduardo D. Sontag jointly with P. Chen
Articles in journal or book chapters
  1. T. Riley, E.D. Sontag, P. Chen, and A. Levine. The transcriptional regulation of human p53-regulated genes. Nature Reviews Molecular Cell Biology, 9:402-412, 2008. [PDF] Keyword(s): Hidden Markov Models, p53, transcription.
    The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.



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Last modified: Thu Apr 11 22:06:19 2019
Author: sontag.

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