BACK TO INDEX

Publications of Eduardo D. Sontag jointly with B. de Freitas Magalh„es
Articles in journal or book chapters
  1. B. de Freitas Magalh„es, G. Fan, E.D. Sontag, K. Josic, and M. Bennett. Pattern formation and bistability in a synthetic intercellular genetic toggle. 2022. Note: Submitted.Keyword(s): synthetic biology, quorum sensing, systems biology, toggle switch.
    Abstract:
    Differentiation within multicellular organisms is a complex process that helps to establish spatial patterning and tissue formation within the body. Often, the differentiation of cells is governed by morphogens and intercellular signaling molecules that guide the fate of each cell, frequently using toggle-like regulatory components. Synthetic biologists have long sought to recapitulate patterned differentiation with engineered cellular communities and various methods for differentiating bacteria have been invented. Here, we couple a synthetic co-repressive toggle switch with intercellular signaling pathways to create a "quorum-sensing toggle." We show that this circuit not only exhibits population-wide bistability in a well-mixed liquid environment, but also generates patterns of differentiation in colonies grown on agar containing an externally supplied morphogen.



BACK TO INDEX




Disclaimer:

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders.




Last modified: Fri Jul 29 12:19:42 2022
Author: sontag.


This document was translated from BibTEX by bibtex2html