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Publications about 'antithetic feedback'
Internal reports
  1. M. Margaliot and E.D. Sontag. Compact attractors of an antithetic integral feedback system have a simple structure. Technical report, bioRxiv 2019/868000v1, 2019. [PDF] Keyword(s): Poincare-Bendixson, k-cooperative dynamical systems, sign-regular matrices, synthetic biology, antithetic feedback.
    Abstract:
    Since its introduction by Briat, Gupta and Khammash, the antithetic feedback controller design has attracted considerable attention in both theoretical and experimental systems biology. The case in which the plant is a two-dimensional linear system (making the closed-loop system a nonlinear four-dimensional system) has been analyzed in much detail. This system has a unique equilibrium but, depending on parameters, it may exhibit periodic orbits. This note shows that, for any parameter choices, every bounded trajectory satisfies a Poincare'-Bendixson property: the dynamics in the omega-limit set of any precompact solution is conjugate to the dynamics in a compact invariant subset of a two-dimensional Lipschitz dynamical system, thus precluding chaotic and other strange attractors.



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Last modified: Thu Sep 24 12:35:48 2020
Author: sontag.


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