Publications of Eduardo D. Sontag jointly with M. Ali Al-Radhawi
Articles in journal or book chapters
  1. M. Ali Al-Radhawi, D. Del Vecchio, and E.D. Sontag. Identifying competition phenotypes in synthetic biochemical circuits. bioRxiv, 2022. [WWW] [doi:10.1101/2022.03.22.485420]
    Synthetic gene circuits require cellular resources, which are often limited. This leads to competition for resources by different genes, which alter a synthetic genetic circuit{ extquoteright}s behavior. However, the manner in which competition impacts behavior depends on the identity of the "bottleneck" resource which might be difficult to discern from input-output data. In this paper, we aim at classifying the mathematical structures of resource competition in biochemical circuits. We find that some competition structures can be distinguished by their response to different competitors or resource levels. Specifically, we show that some response curves are always linear, convex, or concave. Furthermore, high levels of certain resources protect the behavior from low competition, while others do not. We also show that competition phenotypes respond differently to various interventions. Such differences can be used to eliminate candidate competition mechanisms when constructing models based on given data. On the other hand, we show that different networks can display mathematically equivalent competition phenotypes.Competing Interest StatementThe authors have declared no competing interest.



This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders.

Last modified: Fri Jun 24 10:36:54 2022
Author: sontag.

This document was translated from BibTEX by bibtex2html