1. Y. Zarai, M. Margaliot, E.D. Sontag, and T. Tuller. Controllability analysis and control synthesis for the ribosome flow model. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 15:1351-1364, 2018. [PDF] Keyword(s): systems biology, ribosomes, controllability, RFM, ribosome flow model. Abstract:

   The ribosomal density along the coding region of the mRNA molecule affects various fundamental intracellular phenomena including: protein production rates, organismal fitness, ribosomal drop off, and co-translational protein folding. Thus, regulating translation in order to obtain a desired ribosomal profile along the mRNA molecule is an important biological problem. This paper studies this problem formulated in the context of the ribosome flow model (RFM) in which one views the transition rates between site as controls.

1. Y. Zarai, M. Margaliot, E.D. Sontag, and T. Tuller. Controlling the ribosomal density profile in mRNA translation. In Proc. IEEE Conf. Decision and Control, Dec. 2016, pages 4184-4189, 2016. Keyword(s): ribosomes, translation, RFM, ribosome flow model.

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