2017
- ▪L. Yang, E.M. Dolan, S.K. Tan, T. Lin, E.D. Sontag, S.D. Khare, "Computation-guided design of a stimulus-responsive multi-enzyme supramolecular assembly, systems biology", ChemBioChem, vol. 18, pp. 2000-2006, 2017. pdf
Abstract
This paper reports on the construction of a phosphorylation- and optically-responsive supramolecular complex of metabolic pathway enzymes for the biodegradation of an environmental pollutant. Fusing of enzymes led to an increase in pathway efficiency, and illustrates the possibility of spatio-temporal control over formation and functioning of a wide variety of synthetic biotransformations.