News from the Laboratory for Control, Learning, and Systems Biology at Northeastern University

Lectures

• Eduardo Sontag gave keynote at L4DC in Michigan, in June 2025.
• Eduardo Sontag gave three talks at Imperial College, Cambridge, and Oxford in April-May 2025.
• Eduardo Sontag gave four talks at UCSD and UCSB (including the Petar Kokotovic lecture at UCSB) in February-March 2025.

New Publications! (Please consult the publications page for abstracts)

• Paper on global linearizations published in Systems and Control Letters: "Global linearization of asymptotically stable systems without hyperbolicity" M. D. Kvalheim and E. D. Sontag
• Paper on overparametrized LQR accepted for Automatica: "Convergence analysis of gradient flow for overparameterized LQR formulations" Arthur Castello Branco de Oliveira, Milad Siami, Eduardo Sontag
• (2025.04.23) Paper on bispecific T cell engagers accepted for Bulletin of Mathematical Biology
  M. Sadeghi, I. Kareva, G. Pogudin, and E.D. Sontag. . Quantitative pharmacology methods for bispecific T cell engagers. Bulletin of Mathematical Biology, 2025.
• (2025.04.21) Paper on cumulative dose responses accepted for J Royal Society Interface
  A. Gupta and E. D. Sontag. Cumulative dose responses for adapting biological systems. J Royal Society Interface 2025.
• (2025.04.04) Paper on induced resistance in chemotherapy accepted for Nature's npj Systems and Synthetic Biology
  L. Gevertz, J.M Greene, S. Prosperi, N. Comandante-Lou, and E.D. Sontag. Understanding therapeutic tolerance through a mathematical model of drug-induced resistance. npj Systems Biology and Applications, 2025.
• (2024.10.14) Paper on synthetic circuits accepted for Nature Chemical Biology
  J.P. Padmakumar, J. Sun 2, W. Cho 3, Y. Zhou, C. Krenz, Zhong Han W.Z, D. Densmore, E. D. Sontag, and C.A. Voigt. Partitioning of a 2-bit hash function across 66 communicating cells. Nature Chemical Biology, 21:268-279, 2025.