BACK TO INDEX

Publications of Eduardo D. Sontag jointly with S. Legewie
Articles in journal or book chapters
  1. P. Bastiaens, M. R. Birtwistle, N. Bluthgen, F. J. Bruggeman, K.-H. Cho, C. Cosentino, A. de la Fuente, J. B. Hoek, A. Kiyatkin, S. Klamt, W. Kolch, S. Legewie, P. Mendes, T. Naka, T. Santra, E.D. Sontag, H. V. Westerhoff, and B. N. Kholodenko. Silence on the relevant literature and errors in implementation. Nature Biotech, 33:336-339, 2015. [PDF] Keyword(s): modular response analysis, systems biology, biochemical networks, reverse engineering, gene and protein networks, protein networks, gene networks, systems identification.
    Abstract:
    This letter discusses a paper in the same journal which reported a method for reconstructing network topologies. Here we show that the method is a variant of a previously published method, modular response analysis. We also demonstrate that the implementation of the algorithm in that paper using statistical similarity measures as a proxy for global network responses to perturbations is erroneous and its performance is overestimated.



BACK TO INDEX




Disclaimer:

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders.




Last modified: Mon Mar 18 14:40:24 2024
Author: sontag.


This document was translated from BibTEX by bibtex2html